Treatment of Oral Biofilms by a D-Enantiomeric Peptide
Tian (Sally) Zhang
University Hill (Secondary)
Floor Location : 030404

Almost all dental diseases are caused by biofilms that consist of multispecies communities. DJK-5, a novel D-enantiomeric, protease-resistant peptide with broad-spectrum anti-biofilm activity, was tested for its effects on oral multispecies biofilms. A new combination of DJK-5 and chlorhexidine was also evaluated. The 16S rRNA genes from treated sample were amplified, sequenced with Miseq Illumina and analyzed. The results show DJK-5 was very effective against oral biofilms when used alone or combined with chlorhexidine. The peptide modulated microbiome structure, achieving a healthy oral microbiome. DJK-5 may be a promising agent for use in oral anti-biofilm strategies.