Direct Conversion of Fibroblasts to Neurons using the CRISPR-Cas9 System
Floor Location : 030401
Neurons produced using the CRISPR-Cas9 system can be used either therapeutically or for research purposes.
Neurons for neuronal transplant can be produced by collecting fibroblast cells from the patient and altering the gene that codes for the PTB1 protein using CRISPR, thereby trans-differentiating them into neutrons. As these neurons would have the same genetic makeup as the patient, they could be transplanted into the patient’s brain without immune rejection occurring.
Trans-differentiated fibroblasts could also be used for research purposes, allowing scientists to examine the behaviour of a subject’s neurons without having to harvest brain cells.