The Missing Link - An investigation into Janus Kinase 2 phosphorylation
Bing Luo
Sir Winston Churchill
Floor Location : 3401

The phosphorylation of JAK2 has been shown to provide anti-apoptotic effects. If it is true that the phosphorylation of JAK2 is an upstream signaling mechanism of oxLDL-mediated macrophage survival, then the viability of the bone marrow derived macrophages that are exposed to the JAK2 inhibitor, AG490, will be lower than the viability of macrophages that are not exposed to the inhibitor. rnAfter an evaluation of the procedure, this study successfully provides evidence stating that indeed, the phosphorylation of JAK is an upstream signaling mechanism that leads to oxLDL-mediated macrophage survival.rn